2011年毕业于北京大学医学部生物化学与分子生物学专业，获得理学博士学位；2011至2014年北京大学博士后；2014年9月至今，在双身刺客任职。主要研究方向为mRNA修饰介导的基因转录后调控。主持国家自然科学基金、北京市自然科学基金和双身刺客青年教师基金等科研项目。承担本科生《生物化学A》、《生物技术概论》和《生物技术大实验》等课程。目前担任2016级和2017级励耘班辅导员。
RNA修饰是表观转录调控的重要方面。人们发现真核生物的mRNA和ncRNA中都存在大量的m6A和m5C修饰，这些修饰方式在转录后调控过程中（如mRNA前体剪切、mRNA降解及翻译等）中发挥重要作用。本实验室主要利用生物化学、分子生物学、质谱分析、生物信息学等多种研究手段，通过体外实验和条件敲除小鼠分别从细胞和整体两个层面深入探讨介导mRNA基化修饰的RNA甲基转移酶及RNA结合蛋白参与转录后调控的分子机制及其在肿瘤发生，脂质代谢，应激等生物学过程中的功能。
1. Yang Long, Yuqin Wang, Mengxia Qu, Di Zhang, Xiaotian Zhang#, and Junjie Zhang#. Combined inhibition of EZH2 and the autotaxin-LPA-LPA2 axis exerts synergistic antitumor effects on colon cancer cells. Cancer Letters. 2023, 566:216226.
2. Mengxia Qu, Yang Long, Yuqin Wang, Nan Yin, Xiaotian Zhang#, and Junjie Zhang#. Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner. Int J Mol Sci. 2023, 24(8):7031.
3. Xiaotian Zhang, Mengmiao Li, Nan Yin and Junjie Zhang#. The Expression Regulation and Biological Function of Autotaxin. Cells. 2021, 10(4):939. Review
4. Xin Xu, Yihua Zhang, Junjie Zhang#, Xiaotian Zhang#. NSun2 promotes cell migration through methylating autotaxin mRNA. Journal of Biological Chemistry. 2020, 295(52): 18134-18147.
5. Yuqin Wang, Lin Lyu, Xiaotian Zhang# and Junjie Zhang#. Autotaxin is a novel target of microRNA-101-3p. FEBS Open Bio, 2019, 9(4):707-716.
6. Hao Tang, Hu Wang, Xiaolei Cheng, Xiuqin Fan, Fan Yang, Mengmeng Zhang, Yanlian Chen, Yuyang Tian, Cihang Liu, Dongxing Shao, Bin jiang, Yali Dou, Yusheng Cong, Junyue Xing, Xiaotian Zhang, Xia Yi. HuR regulates telomerase activity through TERC methylation. Nature Comunications, 2018, 9(1):2213. doi: 10.1038/s41467-018-04617-7
7. Shuhong Sun*, Xiaotian Zhang*#, Lin Lyu, Xixi Li, Siliang Yao, and Junjie Zhang#. Autotaxin expression is regulated at the post-transcriptional level by the RNA-binding proteins HuR and AUF1. Journal of Biological Chemistry, 2016，219(50): 25823-36.
8. Junwei Ni, Mingyang jiang, Xiaotian Zhang, and et al. Post-transcriptional regulation of Nkx2.5 by RHAU in heart development. Cell Reports, 2015, 13(4): 723-32.
9. Xiaotian Zhang*, Zhenyun Liu*, Jie Yi, and et al. The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3’-untranslated region of p16. Nature Communications, 2012, 3: 712. doi:10.1038/ncomms1692.
